You didn't say if you had a deep sand bed or not (3.5 inches or more). It seems to me that people are having luck with shallow sand beds (1 inch) by not vacuuming but just stirring periodically.
I have been using a DBS for years. Twice now I started DSB systems that ran for about three years each. The first year or two, everything looks great. Then I get an unmanageable hair algae outbreak that I fight for the next two years. It's not much fun. Yeah, I do all of those things you usually hear about, RO/DI, water changes, phosban, snails and crabs, handfulls of hair, ... I now believe that a DSB turns into a toxic nightmare over time, at any depth.
I would think that vacuuming a DSB defeats it's purpose, denitrification (for most people). You're introducing oxygen to the deep layers and removing the anoxic (anaerobic?) bacteria you want. It's way too much work anyway.
Maybe if you start scheduling sections to be vacuumed in a rotation from the beginning it could work. I haven't really tried. Monitor nitrate levels if you do and let us know how it works.
Without a DSB, you need another denitrification strategy.
Jack
Big whorls have little whorls, Which feed on their velocity;
And little whorls have lesser whorls, And so on to viscosity
Lewis Richardson in 1922