Welcome to MAAST! Sorry to hear about your problems.

Sorry, don't know where to find Bio Spiram (have never even heard of it.)

We have used TLC before and also used Amquel+ one time.

Those just treat the symptoms.... What do you think is causing the problem? Bio-load? (too many fish?), have you just added in a bunch of new live stock, or made any changes? Anything dead or missing? Might be decaying and causing a problem.

A big water change might help also... Certainly can't hurt and more than likely is the only thing that will help get those numbers down.

Sorry can't be more help...

Mike (& Kristy)